Explain how cell division is controlled in cells, using examples like MPF and PDGF.
Cells must pass through three checkpoints [in red below] in order to carry out cell division. If a cell does not meet the requirements to pass the checkpoint, it will be unable to continue on to the next phases of cell division.
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| Mastering Biology | Pearson; Campbell Biology |
MPF for example, uses cyclins and cyclin-dependent kinases [Cdks] that come together to form a complex which triggers a cell’s passage past the checkpoints. Cyclin and Cdks concentration gradually increases, peaking at M-phase and fusing together here. After the cell divides, cyclin degrades and is recycled to be used again to create MPF.
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| Mastering Biology | Pearson; Campbell Biology |
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